D.L. Moody emphasizes the significance of every individual soul, particularly in the context of teaching and nurturing young children in faith. He recounts an encounter with a Sunday-school teacher who dismissed her class upon finding only one little boy present. Moody challenges this mindset, asserting that even one child can hold immense potential for greatness and transformation, likening them to historical figures like Knox, Wesley, or Whitefield. The sermon calls for valuing each soul and recognizing the impact they can have on the world.