David Wilkerson emphasizes the transformative journey of surrender through the example of Paul, who was dramatically converted on the road to Damascus. Paul, initially self-assured and misguided, encountered Jesus and realized the emptiness of his previous ambitions. His heart's cry became one of total surrender, seeking to know and please Christ above all else. Wilkerson reminds us that true success in God's eyes is not measured by worldly achievements but by the condition of our hearts and our willingness to follow His will. Ultimately, the sermon calls believers to evaluate their lives and ambitions in light of their surrender to God.