Chuck Smith discusses the concept of 'lying vanities' that lead people away from God's call, using Jonah's attempt to flee from his divine mission as a primary example. He emphasizes that true happiness cannot be found in the pursuit of worldly desires or by resisting God's will, as these are deceptive paths that ultimately lead to misery. Smith warns against the belief that one can find God on their own terms or that the Word of God is irrelevant to them, highlighting the danger of being deceived by Satan. He concludes by urging listeners to submit to God, as resisting Him only leads to forsaking their own mercy and well-being.