Andrew Murray emphasizes the conflict between the Spirit and the flesh, urging believers to recognize that true worship and service to God must be led by the Holy Spirit rather than relying on human effort or self-righteousness. He warns against the subtlety of the flesh, which can masquerade as religious zeal while actually hindering spiritual growth and obedience. Murray highlights the importance of complete surrender to the Spirit, as only through this can one truly glory in Christ Jesus and experience the fullness of life in Him. He calls for a deep trust in the Spirit's leading, reminding believers that confidence in the flesh ultimately leads to spiritual failure. The sermon concludes with a prayer for revelation and strength to overcome the flesh and live a life empowered by the Holy Spirit.