David Wilkerson addresses the concept of 'soul sickness,' which arises from an overwhelming flood of troubles that can leave one feeling hopeless and distressed, much like King David expressed in his psalms. He emphasizes the importance of persistent prayer and maintaining faith, even when circumstances seem dire and God feels distant. Wilkerson reassures listeners that God loves them through their struggles and encourages them to shake off fear and rest in His promises. He reminds us that despite life's challenges, God will never fail those who trust in Him.