Zac Poonen emphasizes that Jesus came to save us from self-centredness, which often infiltrates even our most sacred desires. He explains that true spirituality requires a heart centered on God rather than on personal gain or blessings. Poonen highlights the importance of prioritizing God's glory in our prayers and lives, illustrating that joy and peace stem from being God-centered. He encourages believers to love God and others, as this is the antidote to self-centredness. Ultimately, a genuine spiritual life is marked by a desire for God's presence over His gifts.