F.B. Meyer emphasizes the necessity of substituting the Christ-life for the self-life, arguing that self is the main impediment to spiritual growth. He uses the Epistle of Galatians to illustrate how the works of the flesh manifest in various forms of selfishness and how true sanctification comes through the cross of Christ. Meyer stresses that believers must crucify their self-life and allow the Holy Spirit to lead them into a life centered on Christ. He highlights that the struggle between the flesh and the Spirit is ongoing, and true victory comes from living in the Spirit. Ultimately, the sermon calls for a radical transformation where Christ becomes the center of our lives instead of self.