John Gill emphasizes the respective duties of husbands and wives, highlighting that husbands are called to love their wives as Christ loves the church, while wives are to show reverence and submit to their husbands as to the Lord. He explains that marriage is a sacred institution ordained by God, where both partners are to fulfill their roles with mutual respect and love. The sermon underscores the importance of these duties in maintaining a harmonious and God-honoring household, reflecting the relationship between Christ and the church. Gill also discusses the significance of consent in marriage and the responsibilities that come with it, urging both parties to prioritize each other's well-being and spiritual growth.