A.B. Simpson emphasizes the grave responsibility of Christians to reach out to those who are spiritually perishing, likening their neglect to a crime against humanity. He illustrates the urgency of the situation by comparing it to physical disasters where lives are saved through immediate action, urging believers to recognize the eternal consequences of inaction. Simpson warns that ignorance of the world's needs is no excuse, as God holds us accountable for our opportunities to share the Gospel. He calls for a collective awakening to the plight of the lost and challenges the church to act decisively in spreading the message of salvation. Ultimately, he stresses that every believer must confront their role in this divine mandate and respond with urgency and compassion.