J.C. Ryle emphasizes the grave warning of Jesus to 'Remember Lot's wife,' highlighting her tragic fate despite her religious privileges. Lot's wife, who had the opportunity to witness the faith of righteous men and the miraculous escape from Sodom, ultimately perished due to her attachment to the world and lack of true faith. Ryle warns that mere possession of religious privileges does not guarantee salvation, as many can be surrounded by spiritual advantages yet remain unconverted. He urges listeners to seek the grace of the Holy Spirit, which is essential for true transformation and salvation. The sermon serves as a call to self-examination for all who enjoy religious privileges, reminding them that without genuine faith, they risk the same fate as Lot's wife.