John Gill emphasizes the importance of sanctifying the Lord God in our hearts, which involves recognizing and proclaiming His holiness rather than attempting to make Him holy. He explains that this internal sanctification is crucial for overcoming fear of men and is rooted in a childlike fear of God, grounded in faith and His promises. Gill also stresses the necessity for Christians to be prepared to give a reason for their hope in Christ, doing so with humility and reverence, and being knowledgeable about the foundations of their faith. This readiness to respond is not just for intellectual debate but is a reflection of one's relationship with God and understanding of the Gospel. Ultimately, believers are called to live out their faith authentically and be prepared to share it with others.