Martyn-Lloyd Jones addresses the concept of humanism as the fifth woe pronounced by Isaiah, emphasizing that the Bible remains relevant and contemporary, revealing the timeless nature of human sin and folly. He critiques the pride of intellect that characterizes humanism, arguing that reliance on human wisdom leads to moral decline and rebellion against God. The preacher highlights that true wisdom begins with the fear of the Lord and that human beings must recognize their limitations and need for divine guidance. He warns against the illusion of modernity and the false confidence in human understanding, ultimately calling for humility and faith in Christ as the true source of wisdom and salvation.