David Wilkerson emphasizes the significance of the Passover as a foreshadowing of our deliverance from sin through the blood of Jesus. Just as the Israelites were protected by the blood of the lamb, we are assured safety and power over sin through Christ's sacrifice. The sermon highlights that while sin may still exist in our lives, it does not have dominion over us, and we are empowered to overcome the flesh. Wilkerson encourages believers to remain hopeful and expectant for Christ's return, reminding us of the privilege of being cleansed and prepared as His bride.