Keith Daniel emphasizes the necessity of having a personal Calvary experience to achieve a vital relationship with God and to be effectively used for His purposes. He shares personal anecdotes and biblical principles, illustrating that true fruitfulness in a Christian's life comes from dying to self and fully surrendering to God's will. Daniel challenges the congregation to seek God earnestly and to lay their lives on the altar, highlighting that only through such surrender can they expect God to answer their prayers and bring about transformation in their lives and the lives of others.