Chuck Smith discusses the theme of misguided men, emphasizing how many are led astray by false precepts, false prophets, their own lusts, and the lies of Satan. He illustrates these points with biblical examples, such as the lying prophet in I Kings 13 and Samson's downfall. In contrast, he highlights the importance of being guided by God's word and acknowledging Him in all our ways, suggesting that true guidance comes from a faithful relationship with God. The sermon serves as a reminder of the dangers of following misleading paths and the necessity of divine guidance.