Zac Poonen emphasizes that the greatest honor for believers is to do God's will, as taught by Jesus and the apostles. He warns against the folly of pursuing our own paths without seeking God's guidance, especially when making significant life decisions. Poonen highlights that many miss God's perfect will due to disobedience and compromise, urging believers to earnestly seek God's plan for their lives. He illustrates this with biblical examples, including David and the Israelites, and encourages a life dedicated to fulfilling God's will. Ultimately, he calls for a commitment to walk in God's appointed path, assuring that it leads to true fulfillment and purpose.