Michael Koulianos emphasizes that God is our 'exceedingly great reward,' as demonstrated in His promise to Abram. He explains that God desires a deep, personal relationship with us, where He speaks clearly and intimately, much like He did with Moses. Koulianos highlights the importance of surrendering our blessings back to God, illustrating this with Abram's willingness to sacrifice Isaac, the son God promised him. He encourages believers to recognize that true life comes from dying to self and that God raises what is surrendered to Him. Ultimately, the sermon calls for a deeper fellowship with God, where He becomes our all in all.