A.W. Tozer emphasizes the importance of distinguishing between spiritual burdens and mere irritations that can arise in the life of a Christian. He warns that Christians must be vigilant and prayerful to avoid allowing stress and strain to lead to an irritable spirit, which can tarnish their testimony. Tozer highlights the need for spiritually sensitive individuals who can recognize the faults within the church and call it back to righteousness, drawing parallels to the deep burdens carried by biblical prophets for God's people. He notes that true burdens stem from a genuine concern for God's honor and the souls of men, rather than personal grievances or irritations.