Zac Poonen emphasizes that the sacrifices acceptable to God are those that come from a broken and contrite heart, as exemplified by Abel, in contrast to Cain's prideful offering. He warns against the misconception that merely presenting the blood of Jesus guarantees acceptance, stressing that true faith involves a humble dependence on God. Poonen highlights that God looks at the attitude of our hearts rather than the outward actions, and only those who walk in the light with humility can claim the cleansing power of Jesus' blood. He concludes that humility is essential for salvation and that God stands with the humble while opposing the proud.