Favell Lee Mortimer preaches on the profound significance of Jesus as the good shepherd, emphasizing that He is the gate to God and the only way to salvation through His sacrificial atonement. While there are other shepherds like Christ's ministers, Jesus stands out as the one who offers abundant life both naturally and spiritually by laying down His life for His sheep. The Pharisees, depicted as hirelings in the parable, lacked love for the sheep and failed to protect them, contrasting with Jesus who cares deeply for each lamb in His flock, seeking out the scattered and weak to bring them back to Himself.

John Henry Jowett preaches on the immense value God places on each soul, emphasizing the deep concern and pursuit of the Shepherd for the one lost sheep. Just as a missing face creates a void in a family, a wandering soul leaves a gap in the Father's house. The Shepherd's relentless search in difficult terrains mirrors the lengths to which God goes to seek and save the lost, ultimately rejoicing in the restoration of the lost sheep.

John Gill emphasizes the transformative journey of believers as depicted in 1 Peter 2:25, illustrating how they were once lost sheep, straying from the Shepherd, but have now been brought back through the grace of God. He explains that this return is not by their own efforts but through the powerful work of the Holy Spirit and the sacrificial love of Christ, who is both the Shepherd and Bishop of their souls. Gill draws parallels to Isaiah 53:6, highlighting the elect's need for redemption and the active role of Christ in their salvation.

George Fox emphasizes the transformative power of Christ, the heavenly man, who brings believers from death to life through His blood. He encourages the gathered friends of Christ to remain steadfast in their faith, highlighting the importance of being part of the congregation of the living, which is sustained by Christ as their shepherd and bishop. Fox warns against the dangers of returning to old ways and stresses the necessity of standing firm in the light and truth of the gospel, which empowers believers to overcome trials and tribulations. He reassures them that in Christ, they find eternal rest and a royal inheritance, urging them to keep their focus on Him amidst worldly distractions.

Isaac Penington preaches about the gathering of God's scattered sheep back to the light and Spirit of Christ, emphasizing the importance of being truly holy and sanctified in Christ Jesus. He explains the contrast between the law of sin in the fleshly mind and the law of life and holiness in the renewed mind, highlighting the strength that each law derives from its source. Penington also addresses the grace of the gospel, the righteousness of Christ, and the true knowledge of Christ, urging listeners to heed the inward teachings of God's Spirit for salvation and transformation.