J.R. Miller emphasizes that true life is found in selfless love and sacrifice, illustrated by the parable of the grain of wheat, which must die to produce new life. He reflects on Jesus' own sacrifice, which seemed like a loss but became the source of hope and salvation for humanity. Miller warns against the temptation to prioritize personal comfort and ease over fulfilling our duties to others, asserting that in trying to save our lives, we ultimately lose them. He encourages believers to embrace the hard paths of service and love, as these lead to true fulfillment and eternal life. The sermon calls for a commitment to God's will over self-interest, highlighting that losing one's life in service is the path to true gain.