David Wilkerson emphasizes the spiritual significance of reaching 'wit's end,' a state where human resources and understanding are exhausted, as illustrated in Psalms 107. He explains that God sometimes orchestrates storms in our lives to bring us to this point, where we must relinquish control and fully trust in Him for deliverance. The sermon encourages believers to cry out to God in their troubles, as true help comes only from Him, and highlights that trials are opportunities for faith to grow. Wilkerson reminds us that God has a plan for our deliverance, often prepared long before we face our challenges, and urges us to trust Him completely, even when circumstances seem dire.