C.H. Spurgeon emphasizes that the way of holiness is straightforward and accessible, ensuring that even the simplest individuals can navigate it without error if they remain faithful. He contrasts this with the convoluted paths of worldly wisdom, which often lead to mistakes and misdirection. Spurgeon encourages believers to adhere to truth and integrity, avoiding deceitful shortcuts, as these ultimately lead to greater troubles. He asserts that following God's way, despite being perceived as foolish by others, is the wisest course of action. The sermon concludes with a prayer for divine guidance along the righteous path amidst adversities.