A.W. Tozer emphasizes the tragedy of humanity's unwillingness to yield to God, highlighting that many people, despite understanding the revelation of Jesus Christ, refuse to change their ways and commit to Him. He points out that this resistance stems from a desire to maintain their own selfish interests and kingdoms, leading to a rejection of the salvation and knowledge that comes from sincerely receiving Christ. Tozer laments that while individuals cling to their own desires, they miss the profound relationship and understanding of God that is available through Jesus.