Charles Finney emphasizes the urgency of responding to the Holy Spirit's call, warning that God's Spirit will not always strive with humanity. He explains that the Spirit's striving involves a divine energy that seeks to convince and convict individuals of their sin, but persistent resistance can lead to a point where the Spirit withdraws. Finney outlines the implications of this withdrawal, including hardened hearts, increased guilt, and ultimately, damnation. He urges listeners to recognize the seriousness of their spiritual state and the peril of delaying their response to God's call.

Charles Finney emphasizes the critical nature of the Holy Spirit's striving with humanity, explaining that while the Spirit does strive with individuals, there comes a point when this striving ceases due to persistent resistance. He outlines the implications of this cessation, including the dangers of hardening one's heart and the consequences of being abandoned by the Spirit, which can lead to eternal damnation. Finney warns that the Spirit's withdrawal is not a sign of God's lack of compassion, but rather a necessary response to the sinner's willful rejection of truth. He urges listeners to recognize the urgency of their spiritual state and the importance of responding to the Spirit's call before it is too late.