John Wesley expounds on Matthew 11, emphasizing the significance of John the Baptist as the forerunner of Christ and the fulfillment of prophecy. He highlights the importance of faith in recognizing Jesus as the Messiah, as well as the blessings that come to those who are not offended by Him. Wesley also discusses the contrasting responses of the cities to Jesus' ministry, warning of the consequences of unbelief and the invitation to find rest in Christ. He encourages believers to take on the yoke of Jesus, which is gentle and leads to true peace.