Charles Finney emphasizes the critical nature of the Holy Spirit's striving with humanity, explaining that while the Spirit does strive with individuals, there comes a point when this striving ceases due to persistent resistance. He outlines the implications of this cessation, including the dangers of hardening one's heart and the consequences of being abandoned by the Spirit, which can lead to eternal damnation. Finney warns that the Spirit's withdrawal is not a sign of God's lack of compassion, but rather a necessary response to the sinner's willful rejection of truth. He urges listeners to recognize the urgency of their spiritual state and the importance of responding to the Spirit's call before it is too late.