David Wilkerson emphasizes the 'Holy Ghost school of sympathy,' where tested saints learn through suffering and trials. He highlights that Jesus, who experienced profound rejection and pain, understands our struggles and sympathizes with our weaknesses. The sermon reassures believers that suffering has a divine purpose and is part of the Christian journey, as Paul noted in his letters. Wilkerson encourages the faithful to accept their afflictions as part of God's plan, reminding them that God delivers the righteous from their troubles. Ultimately, he calls for hope, as Jesus has overcome the world, and through Him, we can find strength in our tribulations.