K.P. Yohannan emphasizes the importance of surrendering our confidence in our own abilities and relying solely on God for effectiveness in ministry. He shares experiences from his visit to Last Days Ministries, where untrained individuals accomplished great things through their dependence on Christ. Yohannan illustrates this principle with biblical examples, particularly Moses and Paul, who both had to relinquish their self-reliance to be used powerfully by God. The sermon underscores that true effectiveness comes not from education or skills, but from a heart fully surrendered to God’s will. Ultimately, it is our dependence on God that enables us to bear lasting fruit for His glory.