Mike Bickle emphasizes the profound nature of our union with God as described in John 14:12-24, illustrating how Jesus models an intimate relationship with the Father that believers are invited to share. He explains that this relationship is facilitated by the Holy Spirit, who empowers us to engage in prayer, obedience, and experience God's presence in our lives. Bickle highlights the importance of understanding our identity in Christ and the transformative power of this union, encouraging believers to pursue a deeper connection with God through prayer and obedience to His commandments. The sermon underscores that our relationship with God is not just about belief but involves an active, loving response to His call.