Horatius Bonar emphasizes the futility of human remedies in addressing spiritual afflictions, using Saul's disobedience and subsequent torment as a cautionary tale. He illustrates how Saul's reliance on external comforts, like David's harp, provided only temporary relief without addressing the root cause of his spiritual turmoil. Bonar warns against the modern tendency to seek solace in worldly distractions and religious rituals that fail to bring true healing and reconciliation with God. He contrasts this with David's reliance on divine strength, highlighting that true victory comes from faith in God rather than human contrivances. The sermon calls believers to abandon self-reliance and trust solely in God's power for true transformation.