R.A. Torrey addresses the various hindrances to effective prayer, emphasizing that selfish motives, sin, idolatry, stinginess, unforgiveness, poor marital relationships, and unbelief can all obstruct our communication with God. He illustrates how prayers can be rendered powerless when the focus is on personal gain rather than glorifying God, and he urges believers to examine their hearts for hidden sins and idols. Torrey stresses the importance of approaching God with a pure heart, a spirit of generosity, and a commitment to forgiveness to ensure that prayers are heard and answered.