John Wesley addresses the dire state of the world, highlighting the overwhelming presence of ignorance and vice among the majority of humanity, with only a small fraction professing Christianity. He emphasizes the need for the Gospel to spread universally, as prophesied in Isaiah 11:9, where the earth will be filled with the knowledge of the Lord. Wesley expresses hope that God will work through His Spirit to transform hearts and nations, leading to a time when all will know Him. He reassures that despite current darkness, God's plan for redemption and holiness will ultimately prevail, bringing about a glorious revival of faith across the globe. The preacher concludes with a call to trust in God's power to fulfill His promises and spread His truth to all nations.