John Nelson Darby emphasizes the mission of Jesus as He sends His twelve disciples to the lost sheep of Israel, empowering them to heal and cast out demons. He highlights the urgency of their task amidst the iniquity of the people, warning them of the opposition they would face, including persecution and familial division. The disciples are reminded to rely on God for their needs and to boldly proclaim the message of the kingdom, knowing that their faithfulness would be rewarded. Darby underscores the importance of recognizing Jesus as Emmanuel and the consequences of rejecting His messengers. Ultimately, he calls for a commitment to Christ above all else, assuring that even small acts of kindness towards His followers will not go unnoticed.