Mike Bickle emphasizes the significance of understanding and operating in the gifts of the Holy Spirit, as outlined in 1 Corinthians 12. He stresses that these gifts are available to every believer and encourages the congregation to recognize and act upon the subtle impressions from the Holy Spirit, rather than waiting for dramatic manifestations. Bickle explains the nine gifts, categorizing them into revelation, power, and utterance gifts, and highlights the importance of faith and expression in activating these gifts. He urges believers to value the 'whispers' of the Spirit and to step out in faith to minister to others, thereby experiencing the power of God in their lives.