A.W. Tozer emphasizes the necessity of discerning God's highest will through three key actions: putting away known sin, separating from worldly distractions, and offering oneself to God in faith. He assures that God welcomes all who sincerely seek Him, acknowledging their need for cleansing and healing through Jesus Christ. Tozer highlights that true transformation comes from recognizing our unclean state and turning to Christ, who is the ultimate source of mercy, righteousness, and life. The sermon underscores the importance of faith in experiencing the fullness of God's promises.