F.B. Meyer emphasizes the widespread expectation of a great king's advent during the Nativity, rooted in prophecies and the cultural climate of the time. He illustrates how God reaches out to individuals in familiar contexts, guiding them towards truth, as seen with the Wise-Men following the star. Meyer encourages believers to pursue their own guiding stars, ensuring they align with Scripture, while acknowledging that the message of Jesus often causes unrest among those who resist it. The sermon highlights the importance of divine guidance and the necessity of scriptural confirmation in our spiritual journeys.