J.R. Miller emphasizes the profound significance of the prayer 'Search me, O God,' urging believers to invite God to examine their hearts and reveal hidden sins. He highlights the courage and honesty required to genuinely seek divine scrutiny, contrasting it with the superficial judgments of others. Miller reassures that God's omniscience is a source of comfort for believers, as He understands our struggles and offers mercy. The sermon encourages a willingness to confront our flaws and the transformative power of God's searching light in our lives, leading us toward everlasting life.

Charles Finney emphasizes the necessity of inviting God to search our hearts, especially during times of spiritual darkness, insensibility, or guilt. He outlines various conditions under which this prayer is particularly relevant, such as feeling distant from God or lacking the spirit of prayer. Finney warns against self-deception and the dangers of justifying one's actions through false standards, urging believers to seek divine illumination to uncover hidden sins. He concludes by encouraging persistent prayer and self-examination, reminding the congregation that true spiritual awakening requires a willingness to confront and confess one's shortcomings.