John Wesley emphasizes the importance of discerning the signs of the times, as illustrated in Matthew 16:3, where Jesus rebukes the Pharisees and Sadducees for their inability to recognize the coming of the Messiah despite clear signs. Wesley explains that the times of the Messiah were marked by prophecies and miraculous works that should have been evident to the religious leaders, yet their hearts were veiled by hypocrisy and sin. He draws parallels to the present day, urging Christians to recognize the signs of a coming 'latter-day glory' and the transformative work of God in the world today. Wesley warns that many fail to see these signs due to spiritual blindness and a lack of integrity, just as the Pharisees did. He calls for believers to open their eyes to the work of God and to actively participate in spreading the gospel.