C.H. Spurgeon emphasizes that obedience to God's commands leads to blessings for both individuals and their descendants, as highlighted in Deuteronomy 12:28. He clarifies that while salvation is not earned through works, the blessings associated with obedience remain intact for God's faithful servants. Spurgeon urges believers to heed all of God's words without selective adherence, as true blessedness comes from walking uprightly before the Lord. He warns against the futility of dishonesty and worldly conformity, asserting that genuine integrity aligns with God's pleasure and ultimately leads to prosperity. The sermon reassures that God's blessings extend to future generations of those who faithfully obey Him.