John Nelson Darby discusses the chronological dates in Scripture, emphasizing the importance of understanding the timeline from creation to the birth of the Messiah. He explains how various passages, such as those in Exodus and Daniel, provide a framework for calculating significant periods in biblical history, including the sojourn of the Israelites and the reigns of kings. Darby highlights the significance of the 70 weeks of Daniel in relation to the coming of Christ and the prophetic implications of these timelines. He concludes that while the New Testament lacks specific chronological dates, the fulfillment of prophecy remains crucial for understanding God's plan. The sermon encourages believers to remain alert to the unfolding of God's timeline.