D.L. Moody emphasizes the necessity of waiting for the Holy Spirit's power before engaging in ministry, illustrating that while the disciples received the Holy Spirit initially, they needed to tarry in Jerusalem to be fully empowered for their mission. He warns against the futility of working without divine anointing, as true effectiveness in service comes from being filled with the Holy Spirit. Moody highlights the distinction between having the Spirit within and the Spirit upon, asserting that the latter is essential for impactful witness. He encourages believers to trust in God's timing and to seek His power rather than rushing into work unprepared.

We read in John 20:22: "And when He had said this, He breathed on them, and saith unto them, Receive ye the Holy Ghost." Then see Luke 24:49: "And behold, I send the promise of my Father upon you; but tarry ye in the city of Jerusalem until ye be endued with power from on high." The first passage tells us He had raised those pierced and wounded hands over them and breathed upon them and said, "Receive ye the Holy Ghost." And I haven’t a doubt they received it then, but not in such mighty power as afterward when qualified for their work. It was not in fullness that He gave it to them then, but if they had been like a good many now, they would have said, "I have enough now; I am not going to tarry; I am going to work." Some people seem to think they are losing time if they wait on God for His power, and so away they go and work without unction; they are working without any anointing, they are working without any power. But after Jesus had said "Receive ye the Holy Ghost," and had breathed on them, He said: Now you tarry in Jerusalem until you be endued with power from on high." Read in the 1st chapter of Acts, 8th verse: "But ye shall receive power, after that the Holy Ghost is come upon you." Now, the Spirit had been given them certainly or they could not have believed, and they could not have taken their stand for God and gone through what they did, and endured the scoffs and frowns of their friends, if they had not been converted by the power of the Holy Ghost. But now see what Christ said: "Ye shall receive power after that the Holy Ghost is come upon you; and ye shall be witnesses unto me both in Jerusalem and in all Judea, and in Samaria, and unto the uttermost pasts of the earth." Then the Holy Spirit in us is one thing, and the Holy Spirit on us is another; and if these Christians had gone out and went right to preaching then and there, without the power, do you think that scene would have taken place on the day of Pentecost? Don’t you think that Peter would have stood up there and beat against the air, while these Jews would have gnashed their teeth and mocked him? But they tarried in Jerusalem; they waited ten days. What! you say. What, the world perishing and men dying! shall I wait? Do what God tells you. There is no use in running before you are sent; there is no use in attempting to do God’s work without God’s power. A man working without this unction, a man working without this anointing, a man working without the Holy Ghost upon him, is losing his time after all. So we are not going to lose anything if we tarry till we get this power. That is the object of true service, to wait on God, to tarry till we receive this power for witness-bearing. Then we find that on the day of Pentecost, ten days after Jesus Christ was glorified, the Holy Spirit descended in power. Do you think that Peter and James and John and those apostles doubted it from that very hour? They never doubted it. Perhaps some question the possibility of having the power of God now, and that the Holy Spirit never came afterward in similar manifestation, and will never come again in such power.