David Wilkerson speaks to believers in deep despair, emphasizing the path to victory through diving into God's Word and trusting the Holy Spirit. He encourages individuals to claim God's promises in prayer, reminding them of God's willingness to provide good things to those who ask. Wilkerson highlights the importance of acknowledging the Holy Spirit's presence and guidance in their lives, urging believers to surrender their struggles to Him. By holding onto faith and God's promises, believers can experience refreshing times from the Lord, even in their darkest moments.