John Gill emphasizes the plight of the righteous man, Lot, who lived among the wicked in Sodom, illustrating the sorrow and grief that can accompany such a situation. He highlights how Lot, despite being surrounded by immorality, remained steadfast in his righteousness, unable to bear the sinful actions and language of those around him. Gill explains that Lot's soul was continually vexed by the unlawful deeds he witnessed, showcasing the internal struggle of maintaining one's faith in a corrupt environment.