Mike Bickle addresses the end-time conflict against the spirit of Jezebel, drawing parallels between the Old Testament Jezebel, who opposed Elijah, and the New Testament Jezebel in Revelation, who seduces believers into immorality and idolatry. He emphasizes the need for the church to recognize and resist this spirit, which seeks to dull the conscience and shut down the prophetic voice through sin. Bickle warns that the spirit of Jezebel will escalate to murder and theft, and he encourages believers to stand firm in prayer and righteousness, as God will ultimately bring judgment against this spirit. The sermon highlights the importance of spiritual vigilance and the power of prayer in overcoming the challenges posed by the spirit of Jezebel in the end times.