A.W. Tozer emphasizes the importance of aligning our lives with God's will, highlighting four key areas where our paths may diverge from His: moral standards, way of life, plans, and the acceptance of God's truth. He asserts that true righteousness is found in conforming to Scripture rather than personal moral codes, as human hearts can be deceitful. Tozer encourages believers to submit their plans to God, recognizing that His ways are ultimately better for us. The sermon calls for a deep commitment to God's standards and a willingness to surrender our own desires in favor of His divine guidance.