David Wilkerson emphasizes the need for Christians to learn how to stand up against the enemy, rather than being passive victims of spiritual warfare. He points out that not every misfortune is the devil's doing, as many issues stem from our own disobedience and carelessness. Wilkerson highlights that while Satan is real and active, he cannot attack without God's permission and cannot read our thoughts. He encourages believers to rise up like Gideon, who became fed up with oppression and cried out to God for deliverance. The message calls for a proactive faith that confronts spiritual battles with strength and determination.