David Wilkerson emphasizes that living in complete dependence on God requires understanding two key guidelines. First, believers must trust that the Holy Spirit is eager to reveal God's will, even in the minutiae of life, guiding them through their decisions. Second, unwavering faith in prayer is essential for receiving the strength to obey God's direction, as doubt can hinder one's ability to follow through. Wilkerson reassures that God will communicate clearly to those who earnestly seek His guidance, especially during times of affliction or uncertainty.