William Carey emphasizes the importance of fulfilling the Great Commission given by Jesus to preach the gospel to all nations, highlighting the lack of zeal and perseverance in recent years to spread the message to those still lost in ignorance and idolatry. He refutes the notion that the command to teach all nations was limited to the apostles, pointing out that the promise of God's presence in this work extends to all believers. Carey challenges the excuses of natural impossibility and waiting for providential openings, urging for immediate action in sharing the gospel with those who have not yet heard. He addresses objections about focusing solely on local needs, stressing the urgency of reaching those who lack access to the means of grace and the truth of the gospel.

William Carey preaches about the spread of Christianity from the early days of the apostles to the modern missionaries, highlighting the challenges faced, the miraculous conversions, and the relentless efforts to bring the gospel to all nations. The sermon covers the growth of the church from Jerusalem to the ends of the earth, the persecution faced by the apostles, the conversion of Saul on the road to Damascus, the dispersion of the church, and the missionary journeys of Paul and his companions.

William Carey preaches about the state of the world divided into four parts - Europe, Asia, Africa, and America - highlighting the vast number of people still in pagan darkness, without knowledge of the true God or the gospel of Christ. He discusses the barbarity, cannibalism, and human sacrifices found in many parts of the world, emphasizing the urgent need for spreading the gospel to these unreached areas. Carey also addresses the ignorance, immorality, and hypocrisy among those who bear the Christian name, pointing out the prevalence of errors and looseness of conduct even within Christian communities.

William Carey preaches about the impediments in carrying the gospel among the heathen, addressing concerns such as distance, barbarous living conditions, danger, language barriers, and difficulty in procuring necessities. He emphasizes the importance of overcoming these obstacles through navigation, love for souls, and the spread of the gospel for the civilization and salvation of all people. Carey encourages missionaries to be devoted, courageous, patient, and willing to endure hardships, emphasizing the need for piety, orthodoxy, and a spirit of mission. He highlights the significance of learning languages, cultivating friendships, and relying on the Holy Spirit for success in spreading the gospel to unreached areas.

William Carey emphasizes the importance of fervent and united prayer in promoting God's glorious designs and the expansion of Christ's kingdom. He highlights the necessity of seeking the influence of the Holy Spirit in all endeavors, as without it, all efforts will be in vain. Carey points to the prophecies in Zechariah, indicating that a spirit of grace and supplication will lead to cleansing and the destruction of idols. He encourages Christians to persist in prayer, use means to obtain their requests, and actively engage in missions and evangelism, stressing the need for unity and cooperation among believers of all denominations.