In this sermon, the speaker emphasizes the importance of setting our affection on heavenly things and pursuing the high calling of God. He encourages everyone to recognize that God has a personal call for each individual, regardless of the size or significance in the eyes of others. The speaker urges listeners to faithfully serve God in whatever capacity they are called, whether it be in mundane tasks or in more visible roles. He shares a testimony of his own transformation from a life of chasing worldly pleasures to being called by God and experiencing a complete change. The sermon concludes with gratitude for the message and testimonies shared, highlighting the need to be separate and seek the things that are above.